Non-profit · founded 1990

Discovery Institute

Seattle, United States · discovery.org

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Citations, last 5 years: 139
Works, last 5 years: 72
h-index: 40
Scientists listed: 12
Grants since 2016: 829

Grants received

2022–2027 · research · R01

Augmented Notch signaling as a therapeutic approach for Alagille Syndrome

P. Duc Si Dong · Discovery Institute · funded by National Institutes of Health

$411.8kPediatric Hepatobiliary Diseases and Treatments

2022–2025 · research · R01

Preclinical discovery of novel farnesyltransferase inhibitors for the treatment of Alzheimer's disease and related tauopathies

Steven H Olson · Discovery Institute · funded by National Institutes of Health

$878.2kAlzheimer's disease research and treatments

2022–2027 · research · R01

Augmented Notch signaling as a therapeutic approach for Alagille Syndrome

P. Duc Si Dong · Discovery Institute · funded by National Institutes of Health

$429kPediatric Hepatobiliary Diseases and Treatments

2022–2027 · research · R35

Molecular mechanisms underlying the assembly of the human proteasome and endogenous protein complexes

Jianhua Zhao · Discovery Institute · funded by National Institutes of Health

$487.5kUbiquitin and proteasome pathways

2022–2025 · research · R01

Brain-penetrant GPR88 agonists as novel therapeutics for opioid abuse

Michael Jackson · Discovery Institute · funded by National Institutes of Health

$2.2MReceptor Mechanisms and Signaling

2022–2024 · grant · S10

Cytek Aurora Full Spectrum Flow Cytometer

Yoav Altman · Discovery Institute · funded by National Institutes of Health

$468.3kSingle-cell and spatial transcriptomics

2022–2026 · cooperative agreement · U54

Spatial mapping senescent cells across the mouse lifespan by multiplex transcriptomics and epigenomics

Peter D. Adams · Discovery Institute · funded by National Institutes of Health

$2.7MTelomeres, Telomerase, and Senescence

2022–2024 · research · R21

Epigenetic drift of the Aging Heart in Drosophila

Maria Clara Guida · Discovery Institute · funded by National Institutes of Health

$243.8k

2022–2027 · research · R35

Molecular mechanisms underlying the assembly of the human proteasome and endogenous protein complexes

Jianhua Zhao · Discovery Institute · funded by National Institutes of Health

$487.5kUbiquitin and proteasome pathways

2022–2024 · career development · K99

Mitonuclear signaling pathways in senescence-associated inflammation

Karl Nathan Miller · Discovery Institute · funded by National Institutes of Health

$118kTelomeres, Telomerase, and Senescence

2022–2027 · research · R01

Augmented Notch signaling as a therapeutic approach for Alagille Syndrome

P. Duc Si Dong · Discovery Institute · funded by National Institutes of Health

$429kPediatric Hepatobiliary Diseases and Treatments

2022–2025 · research · RF1

Elucidating a microgliaassociated role for SORLA in modulating AD pathogenesis

Timothy Yikai Huang · Discovery Institute · funded by National Institutes of Health

$2.8MNeuroinflammation and Neurodegeneration Mechanisms

2022–2024 · research · R01

GCDH Addiction in Melanoma

Steven H Olson · Discovery Institute · funded by National Institutes of Health

$401.1k

2022–2025 · research · R21

Exploratory Therapy for the Skeletal/Dental Phenotype in PHOSPHO1 Deficiency

Jose Luis Millan · Discovery Institute · funded by National Institutes of Health

$241.3kAlkaline Phosphatase Research Studies

2022–2024 · fellowship · F99

The role of the CCR4-NOT complex in the regulation of Nuclear Pore Complex assembly

Stephen Sakuma · Discovery Institute · funded by National Institutes of Health

$35.3kNuclear Structure and Function

2022–2027 · research · R01

EPHA2 Receptor Signaling in Breast Cancer Mechanotransduction

Elena B Pasquale · Discovery Institute · funded by National Institutes of Health

$551.6kAxon Guidance and Neuronal Signaling

2022–2025 · research · R01

Preclinical discovery of novel farnesyltransferase inhibitors for the treatment of Alzheimer's disease and related tauopathies

Steven H Olson · Discovery Institute · funded by National Institutes of Health

$942.1kAlzheimer's disease research and treatments

2022–2024 · research · R21

Novel Strategy to Quantitate Delayed Aging by Caloric Restriction

Alexey V Terskikh · Discovery Institute · funded by National Institutes of Health

$298.7kEpigenetics and DNA Methylation

2022–2024 · research · R21

Novel Strategy to Quantitate Delayed Aging by Caloric Restriction

Alexey V Terskikh · Discovery Institute · funded by National Institutes of Health

$410.9k

2022–2025 · research · R01

Characterization, optimization, and development of dual mGlu2/3 positive allosteric modulators for opioid use disorder

Nicholas David Cosford · Discovery Institute · funded by National Institutes of Health

$6.4M

2022–2027 · research · R35

Molecular mechanisms underlying the assembly of the human proteasome and endogenous protein complexes

Jianhua Zhao · Discovery Institute · funded by National Institutes of Health

$487.5kUbiquitin and proteasome pathways

2022–2024 · fellowship · F99

The role of the CCR4-NOT complex in the regulation of Nuclear Pore Complex assembly

Stephen Sakuma · Discovery Institute · funded by National Institutes of Health

$35.9kNuclear Structure and Function

2022–2026 · research · R01

Comparative resistomics of Gram-negative bacterial pathogens

Andrei L Osterman · Discovery Institute · funded by National Institutes of Health

$733.5k

2022–2027 · research · R01

Molecular Pathogenesis of AF10-Rearranged Leukemias

Aniruddha J. Deshpande · Discovery Institute · funded by National Institutes of Health

$441.6kAcute Myeloid Leukemia Research

2022–2026 · research · R01

Comparative resistomics of Gram-negative bacterial pathogens

Andrei L Osterman · Discovery Institute · funded by National Institutes of Health

$733.5k

2022–2027 · research · R01

GCDH Addiction in Melanoma

Steven H Olson · Discovery Institute · funded by National Institutes of Health

$736.4k

2022–2024 · research · R61

Optimization of fibroblast-selective inhibitors of YAP/TAZ as novel therapeutics for Pulmonary Fibrosis

Andrew Jon Haak · Discovery Institute · funded by National Institutes of Health

$643.5kHippo pathway signaling and YAP/TAZ

2022–2026 · cooperative agreement · U54

Spatial mapping senescent cells across the mouse lifespan by multiplex transcriptomics and epigenomics

Peter D. Adams · Discovery Institute · funded by National Institutes of Health

$2.7MTelomeres, Telomerase, and Senescence

2022–2026 · research · R01

Microglial heparan sulfate in the modulation of APOE function and neurodegeneration

Yu Yamaguchi · Discovery Institute · funded by National Institutes of Health

$581kProteoglycans and glycosaminoglycans research

2022–2025 · research · R01

Preclinical discovery of novel farnesyltransferase inhibitors for the treatment of Alzheimer's disease and related tauopathies

Steven H Olson · Discovery Institute · funded by National Institutes of Health

$894.6kAlzheimer's disease research and treatments

2022–2026 · research · R01

Microglial heparan sulfate in the modulation of APOE function and neurodegeneration

Yu Yamaguchi · Discovery Institute · funded by National Institutes of Health

$581kProteoglycans and glycosaminoglycans research

2022–2027 · research · R01

Targeting ER+ Breast Cancer Through Induced Viral Mimicry

Charles H. Spruck · Discovery Institute · funded by National Institutes of Health

$441.7k

2022–2026 · cooperative agreement · U54

Spatial mapping senescent cells across the mouse lifespan by multiplex transcriptomics and epigenomics

Peter D. Adams · Discovery Institute · funded by National Institutes of Health

$2.6MTelomeres, Telomerase, and Senescence

2022–2027 · research · R01

GCDH Addiction in Melanoma

Steven H Olson · Discovery Institute · funded by National Institutes of Health

$721.7k

2022–2025 · career development · K99

Mitonuclear signaling pathways in senescence-associated inflammation

Karl Nathan Miller · Discovery Institute · funded by National Institutes of Health

$118kTelomeres, Telomerase, and Senescence

2022–2026 · research · R01

Function and Mechanism of the Hippo-PI5P4K Axis for Growth Control

Brooke M Emerling · Discovery Institute · funded by National Institutes of Health

$556kHippo pathway signaling and YAP/TAZ

2022–2027 · research · R01

Molecular Pathogenesis of AF10-Rearranged Leukemias

Aniruddha J. Deshpande · Discovery Institute · funded by National Institutes of Health

$427.1kAcute Myeloid Leukemia Research

2022–2027 · research · R01

Targeting ER+ Breast Cancer Through Induced Viral Mimicry

Charles H. Spruck · Discovery Institute · funded by National Institutes of Health

$437.1k

2022–2024 · research · R61

Optimization of fibroblast-selective inhibitors of YAP/TAZ as novel therapeutics for Pulmonary Fibrosis

Andrew Jon Haak · Discovery Institute · funded by National Institutes of Health

$618.9kHippo pathway signaling and YAP/TAZ

2022–2027 · research · R01

EPHA2 Receptor Signaling in Breast Cancer Mechanotransduction

Elena B Pasquale · Discovery Institute · funded by National Institutes of Health

$520.5kAxon Guidance and Neuronal Signaling